MAPT and Alzheimer disease: At themolecular level, excessive production of reactive oxygen species (ROS),chronic inflammation, and protein aggregates, such as amyloid-beta(Aβ) plaques and hyperphosphorylated tau tangles, are recognizedcontributors to disease progression. Amongthese, tau hyperphosphorylation and Aβ accumulation are particularlywell-documented hallmarks of AD.