CFTR and hypogonadism: Known contributing factors of low bone mineral density (BMD) include malnutrition, CF transmembrane conductance regulator (CFTR) protein dysfunction, calcium, vitamin D, and vitamin K deficiency, delayed puberty and hypogonadism, decreased physical activity, exogenous glucocorticoids, respiratory infections and systemic inflammation, and CF‐related diabetes (CFRD) and liver disease [1, 2, 3].