NLRP3, inflammasome activation playing a core role in chronic inflammation including immunosuppression, proliferation, angiogenesis, and metastasis, as with breast cancer and cutaneous squamous cell carcinoma (Figure 3); on the contrary, it can also play a tumor suppressive role in relevant colitis and colitis‐associated colorectal cancer (CA‐CRC) [72]. This evidence concerns the gene NLRP3 and colorectal cancer.