In a mouse model of oxidized azomethane‐dextran sodium sulfate (AOM‐DSS)‐induced colon cancer, Nlrp3 knockout mice were more likely to develop colon polyps and were highly sensitive to AOM/DSS‐induced CA‐CRC in a carcinogenic model that exhibited accelerated tumor growth accompanied by colon IL‐18 levels were dramatically reduced. Here, NLRP3 is linked to colorectal carcinoma.