In addition, early atherosclerosis and inflammation‐dependent IL‐18 levels were significantly reduced in mice given low‐density lipoprotein receptor‐deficient mice reconstituted with bone marrow transplantation of Nlrp3‐deficient, Asc‐deficient, or Il‐1α/β‐deficient mice and fed a high‐cholesterol diet [66]. Here, NLRP3 is linked to atherosclerosis.