KPNB1 and neoplasm: Furthermore, it has been shown that tumor cell types exhibited heightened sensitivity to the knockdown of KPNB1 compared to various other importins, suggesting that elevated levels or activity of KPNB1 may play a crucial role in driving tumor progression.[59] Due to high basal ARID1B expression and its long protein half‐life (∼48 h) in MDA‐MB‐468 cells, longer IPZ treatment was required to observe significant cytoplasmic enrichment and nuclear depletion of ARID1B by immunofluorescence (Figure S14D,E).