For example, NF-κB-mediated JMJD3 activation in microglia promotes neurodegeneration in diseases like ALS, Parkinson’s, and Alzheimer’s diseases [39, 40, 41], and our prior work demonstrated NF-κB–JMJD3–MMP signaling in BSCB disruption after SCI [13]. Here, KDM6B is linked to early-onset autosomal dominant Alzheimer disease.