BIK and neoplasm: At higher concentrations, autophagy and lysosome biogenesis genes, such as SQSTM1/p62, LAMP2, and PINK1, were robustly upregulated along with tumor suppressors, such as PTEN, and pro-apoptotic factors, including BAD and BIK, which reinforce autophagic flux and promote cellular homeostasis (Fig. S8).