BCR and leukemia: Chronic myeloid leukemia (CML) comprises approximately 15% of adult leukemia diagnoses and is characterized by a reciprocal translocation t(9;22)(q34;q11.2) involving the Abelson murine leukemia viral oncogene homolog (ABL)1 and breakpoint cluster region (BCR) genes, resulting in the Philadelphia chromosome and BCR-ABL oncoprotein, which drives proliferation and survival [1, 2].