Clusterin has been demonstrated to promote cancer cell survival, proliferation, and metastasis through signaling cascades such as adenosine monophosphate–activated protein kinase/mechanistic target of rapamycin/Unc-51 like autophagy activating kinase 1 [93] and AKT/GSK3β/β-catenin [94] pathways. The gene discussed is CLU; the disease is cancer.