AdipoRon-induced expression of AMPK, PPARα, PGC-1α, and Nrf2 through both AdipoR1 and AdipoR2 are involved in regulating MCT1/2/4 and may support cellular functions by increasing lactate and ATP levels in the sciatic nerve in type 2 diabetic mice. This evidence concerns the gene ADIPOR1 and type 2 diabetes mellitus.