Integrated RNA-sequencing and lipidomics analyses identified several key genes associated with lipid metabolism, including FOS, FOSB, JUN, NR4A1, JUNB, and PPARG. Additionally, pathways related to osteoclast differentiation, Th1 and Th2 cell differentiation, Th17 cell differentiation, the IL-17 signaling pathway, fluid shear stress, and atherosclerosis were implicated. The gene discussed is FOSB; the disease is atherosclerosis.