In preclinical models of sepsis, a life-threatening condition caused by a dysregulated host response to infection (Singer et al, 2016), signal blockade of CASP4 or CASP11 protected from organ damage and death (Cheng et al, 2017; Deng et al, 2018; Hagar et al, 2013; Kayagaki et al, 2013; Wei et al, 2024). This evidence concerns the gene CASP4 and Sepsis.