Based on our preliminary study and other team’s work, SDF-1 binds to its receptor CXCR4 or CXCR7 on endothelial cells, stimulating their migration and proliferation, which promotes pathological angiogenesis in choroidal neovascularization (CNV) (Li et al. 2021). Here, CXCL12 is linked to choroidal neovascularization.