When stratifying for Aβ status and syndrome diagnosis, the prevalence of tau positivity in the temporal cortex was 2.1% (102 of 4,968) in Aβ-negative CU participants versus 20.0% (443 of 2,218) in Aβ-positive CU participants, 6.4% (55 of 863) in Aβ-negative participants with MCI versus 58.1% (731 of 1,258) in Aβ-positive participants with MCI and 10.0% (52 of 522) in participants with Aβ-negative dementia versus 83.5% (1,445 of 1,730) in participants with Aβ-positive dementia (Extended Data Fig. 1b,c). The gene discussed is MAPT; the disease is Down syndrome.