The observed prevalence of tau PET positivity in the temporal cortex was 7.6% (558 of 7,394) in CU individuals, 36.8% (801 of 2,177) in participants with MCI and 64.4% (1,595 of 2,477) in participants with all-cause dementia (Extended Data Fig. 1a). Here, MAPT is linked to dementia.