In models adjusting for age and Aβ pathology, APOE ε4 carriership was associated with a higher prevalence of tau positivity in the temporal cortex in all diagnostic groups (β = 0.55 for CU, β = 0.64 for MCI and β = 0.59 for dementia; all P < 0.001; Fig. 3a,c and Supplementary Table 6). The gene discussed is APOE; the disease is dementia.