We included 12,048 participants with tau PET from 42 cohorts worldwide, of whom 7,394 were CU participants (mean age: 68.7 ± 11.1 years, 55.9% women, 30.9% Aβ positive), 2,177 with MCI (mean age: 71.3 ± 8.8, 45.0% women, 59.3% Aβ positive) and 2,477 with dementia (mean age: 69.9 ± 9.0, 50.9% women, 76.8% Aβ positive; Table 1). Here, MAPT is linked to dementia.