Logistic generalized estimating equation (GEE) models showed significant interactions between age and biomarker-defined Aβ status on tau positivity in the temporal cortex in CU participants and those with MCI and dementia (β, the estimated regression coefficient, = −0.06 for CU, β = −0.09 for MCI and β = −0.09 for dementia, all P < 0.001; Fig. 1a,c). Here, MAPT is linked to dementia.