There is also a trend for an increase in the percentage of PSD95 puncta colocalizing with AT8 in slices cultured with Tau +ve PSP brain extract, compared to slices cultured in medium alone or Tau −ve PSP extract (Fig. 7c); however, the effect size is smaller compared to T22, and over tenfold more postsynapses took up T22 than AT8-positive tau. Here, MAPT is linked to supranuclear palsy, progressive, 1.