In contrast, apoA-II has been reported to inhibit the phosphorylation of ERK1/2 (extracellular signal-regulated kinase 1/2) and transcription factor Jun (c-Jun)40, which is a hallmark of activated peritoneal macrophages in patients with cirrhosis and correlates with augmented IL-6 secretion41. The gene discussed is JUN; the disease is Cirrhosis.