In all models AF apoA-II > 45 μg/ml during SBP remained a predictor of transplant or death after adjustment for the presence of acute-on-chronic liver failure (ACLF) grade 2/3 alone (model 1, adjusted hazard ratio [HR] 2.89; 95% confidence interval [CI]: 1.25–6.71; P = 0.01), age and ACLF grade 2/3 (model 2, adjusted HR 2.59; 95% CI: 1.11–6.04; P = 0.03), or for age and MELD score (model 3, adjusted HR 2.53; 95% CI: 1.08–5.91; P = 0.03) (Table 3). The gene discussed is APOA2; the disease is atrial fibrillation.