Since molecular mechanisms of tumor adaptation to glucose starvation are similar to the ones promoting tumorigenesis [25, 50], and since we and others reported that 4EBP1 promotes tumorigenesis of glioblastoma and Ewing’s sarcoma cells in vivo [25, 27], we explored 4EBP1 function in MB cells growth in vitro. The gene discussed is EIF4EBP1; the disease is Ewing sarcoma.