We categorized the epithelial tumor cells into three subgroups: proliferating (Mki67, Top2a, Hmgb2, etc., as marker genes), luminal (Lrg1, Clu, Muc15, etc., as marker genes), and basal (Acta2, Krt5, Krt14, etc., as marker genes) (Fig. 3a, b), in which the proportions of both proliferating and basal subgroups of tumor cells increased, while the luminal subpopulation decreased in mice exposure to stress stimuli (Fig. 3c). The gene discussed is CLU; the disease is neoplasm.