FAT1 and cancer: FAT1 mutations have been frequently reported in ESCC, and knockdown or endogenous expression loss of FAT1 has been shown to accelerate cell migration and invasion.41KMT2D, a histone methyltransferase, plays a pivotal role in epigenetic regulation and has been implicated in various cancers as a potential oncogene.42 Although our co-mutation analysis revealed that FAT1-KMT2D co-mutations were associated with a trend toward better prognosis, this survival benefit was not significantly greater than that conferred by FAT1 mutation alone.