Professor Dr. Wolfgang F. Graier, head of the NIKON-Center of Excellence at the Medical University of Graz, addressed “Revisiting the Dogma of Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells.” His research challenged conventional wisdom on insulin secretion mechanisms by showing various metabolic pathways influencing pancreatic beta-cell activity and their implications for diabetes treatment. Here, INS is linked to diabetes mellitus.