In HNSCC patients with lymph node metastases (T2–4N1M0), serum levels of FSCN1 were 10-fold higher than in patients without clinically confirmed regional lymph node metastases (T1–4N0M0; P < 0.05; Fig. 1A). The gene discussed is FSCN1; the disease is head and neck squamous cell carcinoma.