Therefore, we hypothesized that data integration of persistently up-regulated genes (Figure 1) and IBD-relevant T cell clusters (cl11.1, cl11.2, cl7, cl17, cl18, cl1, cl3, cl14, and cl15; Figure 2) could exploit inter-patient variability to discover distinct features of an IBrD signature. The gene discussed is ADGRL3; the disease is inflammatory bowel disease.