Recent study [44] have suggested that malignant tumors, including melanomas, may disrupt systemic homeostasis by producing neuroendocrine mediators such as corticotropin-releasing hormone (CRH), proopiomelanocortin (POMC)-derived peptides (e.g., ACTH), and melatonin, thereby hijacking the host’s neuroendocrine network to favor tumor progression. This evidence concerns the gene POMC and neoplasm.