This compensation, however, probably prevented a more marked decrease in NCC phosphorylation and activity which is why no marked electrolytic derangements were observed other than a tendency to hypokalemia [table S1; female wild type (WT): 2.68 ± 0.6 mequiv/liter versus female KO: 2.37 ± 0.47 mequiv/liter, P = 0.141; male WT: 2.69 ± 0.6 mequiv/liter versus male KO: 2.17 ± 0.5 mequiv/liter, P = 0.055]. The gene discussed is SLC12A3; the disease is Hypokalemia.