In the context of retinal degeneration, studies have revealed that while both CTRP9 and adiponectin can bind AdipoR1, the knockout of either gene results in milder retinal phenotypes compared to AdipoR1 knockout mice, with adiponectin-deficient mice exhibiting virtually no retinal abnormalities (50, 51). The gene discussed is ADIPOQ; the disease is retinal degeneration.