Out of the selected studies, 104 described the association between the MTHFR C677T polymorphism and CRC susceptibility, while 60 studies described MTHFR A1298C.The analysis included 37 studies on Asians, 50 on Caucasians, 6 on Indians, 4 on Africans, and 7 on mixed-race populations. This evidence concerns the gene MTHFR and colorectal carcinoma.