And the finding demonstrated a strong correlation between elevated levels of immune checkpoints and the SREBF1 in ACC, notably KIR2DL3, IL2RA, CD80, IFNG, BTN3A2, and IL1A, also IFNA1 wass significantly associated with SREBF1 in the majority of cancers (Fig 4C). Here, IFNA1 is linked to adrenal cortex carcinoma.