Additionally, the TNF and p53 signaling pathways were common, with regulatory involvement from genes such as RHGAP1, SLC10A1, and SIX5. P53 appears to contribute to liver steatosis in MASH patients by inducing the miR-34a-HNF4α pathway. The gene discussed is HNF4A; the disease is metabolic dysfunction-associated steatohepatitis.