In cystic lesions, biochemical tests on cystic fluids should be included in the diagnostic work-up, particularly the determination of carcinoembryonic antigen (CEA) and amylase levels, to aid in the differential diagnosis with intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm, and cystic acinar cell carcinoma [12, 13]. The gene discussed is CEACAM5; the disease is pancreatic intraductal papillary-mucinous neoplasm.