The same study further reported that "methylome profiles of tectal gliomas form a distinct cluster on the t-SNE plot regardless of the mutation status (KRAS only, BRAF only, or combined KRAS/BRAF alterations) [58]." This suggests that tectal gliomas, which morphologically resemble pilocytic astrocytoma, exhibit a methylome profile different from pilocytic astrocytoma. Here, BRAF is linked to central nervous system cancer.