Chiang et al. [58] investigated genetic alterations in tectal gliomas and reported a high frequency of hotspot KRAS G12R mutations (19/23, 82.6%) and BRAF alterations (14/23, 60.9%), while none had alterations in IDH1/2, TP53, ATRX, histone H3 genes, MYB, or MYBL1. The gene discussed is IDH1; the disease is central nervous system cancer.