ACHE and nervous system disorder: There is a dire need to explore in detail the underlying mechanism by which natural nutraceutical like Vitamin D3 (VD) decreases acetylcholine esterase (AChE) activity (Fig. 2), along with its anti-inflammatory, antioxidant, and neuroprotective benefits in neurological disorders (Manjari et al. 2022; Skv et al. 2024).