In a transgenic mouse model of AD activation of α7nAChRs using its specific agonist, PNU-282987 attenuated the Aβ-induced cell apoptosis, decreased the deposition of Aβ, increased the expression of synaptic-associated proteins, and maintained synaptic morphology (Wang et al. 2020b). The gene discussed is CHRNA7; the disease is Alzheimer disease.