The anti-depressive role and cognitive enhancement mediated by α7nAChRs specific full agonists or partial agonists or positive allosteric modulators (PAMs) are observed in neuropsychiatric disorders like depression and SCZ (Eskildsen et al. 2014; McLean et al. 2016; Marcus et al. 2016; Neves and Grace 2018; Wang et al. 2020a; Unal et al. 2021; Targowska-Duda et al. 2021; Lv et al. 2023; Alzarea et al. 2024; Yang et al. 2024; Ongnok et al. 2024). The gene discussed is CHRNA7; the disease is major depressive disorder.