Since α7nAChRs undergo significant downregulation in various mental disorders, causing cognitive deficits and other symptoms, a multidrug-conjugated approach utilizing VD and deeper insights into α7 structure–function analysis may lead to better remedies in the field of neurodegenerative and neuropsychiatric disorders (Tregellas and WyLie 2019; Potasiewicz et al. 2020; Phenis et al. 2020; Burke et al. 2024; Gajendra et al. 2024; ZHuang et al. 2024). The gene discussed is IGKV2D-24; the disease is psychiatric disorder.