This study demonstrates that using radiomics, it is possible to predict programmed death ligand 1 (PD-L1) expression status in non-small cell lung cancer (NSCLC) patients based on 2-deoxy-2-[18 F]-fluoroglucose-positron-emission tomography/computed tomography (18 F-FDG-PET/CT) images. Here, CD274 is linked to non-small cell lung carcinoma.