We cannot exclude that additional factors may contribute to the decrease in pathogen density; however, the fact that restoration of mucin production via two different means, together with that mucin bind and disseminate H. pylori and mice lacking the Muc1 or Muc5AC mucins have higher H. pylori densities after infection than wild-type mice [18–20,52], support that restoration of mucin production contributes to removing H. pylori from its gastric niche. The gene discussed is MUC1; the disease is infection.