Notably, ALP plays a significant role in guiding the self‐assembled peptide system, especially in improving the targeting function, achieving morphological transformation, and promoting radiosensitization.[110] As depicted in Figure11A, our group developed a cananomodulator (CAP‐P‐NO) consisting of a self‐assembled peptide integrating capsaicin (CAP) and nitric oxide (NO), which self‐assembled into dense nanofiber structures under ALP catalysis.[111] When CAP‐P‐NO reached the tumor site, CAP and NO were released in response to intracellular GSH and the extracellular pH (Figure 11B,C). This evidence concerns the gene BRD4 and neoplasm.