MPPE1 and pancreatic neoplasm: Interestingly, in pancreatic tumors lacking HIF‐1α, hypoxia leads to glycogen accumulation and the secretion of IL‐1β and IL‐8, which recruit proangiogenic cDC1 and cDC2 subsets, demonstrating an HIF‐1α‐independent mechanism of immune modulation and tumor progression [80].