In the KPC pancreatic cancer model (LSL‐KrasG12D/+;LSL‐Trp53R172H/+;Pdx‐1‐Cre), high serum IL‐6 levels were associated with reduced cDC1 numbers, which correlated with increased cell death of mature cDC1s [62].Using IL‐6‐expressing EL4 cells and in vitro cultures of cDC1 precursors, it was demonstrated that tumor‐derived IL‐6 directly impairs cDC1 differentiation from hematopoietic progenitors by blocking pre‐cDC1 specification through C/EBPβ induction. Here, MPPE1 is linked to familial pancreatic carcinoma.