Although it was previously thought that apoptosis-related caspases (e.g., caspases 3 and 8) could not stimulate GSDMD-induced pyroptosis, recent studies have found that chemotherapeutic agents can induce caspase-3-mediated cleavage of highly expressed GSDME, leading to tumor cell pyroptosis [27,28]. The gene discussed is CASP3; the disease is neoplasm.