Additionally, it is a common practice in research to construct mouse models of temporal lobe epilepsy in laboratory settings (18), which explains the prominence of keywords such as “mouse,” “expression,” and “model.” Current research primarily focuses on the imbalance mechanisms of neurotransmitters mediated by ion channels and transporters, such as mutations in sodium channels (19), abnormal regulation of potassium channels (20), dynamic imbalances in calcium channels (21), and new discoveries related to transporters (22). Here, KCNA3 is linked to temporal lobe epilepsy.