After adjusting for multiple factors, including age, sex, drinking status, smoking status, cancer, CLD, CKD, hypertension, diabetes, HDL, LDL, TC, HGB, CRP, WBC, PLT, HBA1c, CYSC, UA, and eGFR, a non-linear relationship between TyG-WWI and stroke incidence was also observed. This evidence concerns the gene CYGB and diabetes mellitus.