In Model III, which included additional covariates such as drinking status, smoking status, cancer status, CLD status, CKD status, hypertension status, diabetes status, HDL, LDL, TC, HGB, CRP, WBC, PLT, HBA1c, CYSC, UA, and eGFR, the association remained statistically significant, with an HR of 1.01 (95% CI 1.00–1.03, p = 0.0433). The gene discussed is CRP; the disease is chronic kidney disease.