The CRP as marker of the elevated inflammatory state including albumin (the ratio of CRP to albumin-CAR) is used in predicting long-term mortality among heart failure with reduced ejection fraction (HFrEF) patients with implantable cardiac defibrillators as well as for the prediction of atrial fibrillation recurrence following cryoablation [7, 8]. The gene discussed is ALB; the disease is heart failure.