NGFR and neoplasm: As noted above, NGFR+ (set B) locally advanced specimens with Breslow depth >4mm were an outlier in this analysis, and had the lowest entropy of all specimens in the cohort; whether this represents a general evolution of tumor state to greater homogeneity or is a feature of a minority of specimens is not yet known (Fig. 5B, Supplementary Fig. S7D–F).