MITF and melanoma: Separation along PC2 corresponded to the strength of the MITF signature, consistent with the idea that MITF functions as a molecular rheostat.15 MITF-intermediate states were observed in normal HRs (green outline, Fig. 3F,G, Supplementary Fig. S3H), MITF-high (“hyper-pigmented”) states in invasive melanoma (red outline), and MITF-low dedifferentiated neural-crest like states in invasive VGP HRs (blue outline).