We quantified intermixing using local Shannon entropy, with neighbors defined by Delaunay triangulation on tumor cells (ignoring stromal or immune cells), and cell states as defined in Fig. 2A (e.g., SOX10+ MART1+ SOX9− vs. SOX10+ MART1+ SOX9+ vs. SOX10+ MART1− SOX9−). This evidence concerns the gene MLANA and neoplasm.