The proportions of melanocytic, transitional, mesenchymal, and neural-crest (NC) like tumor cells in each HR were determined based on patterns of SOX10, MART1, SOX9, and NGFR marker co-expression; this showed that the majority of melanocytes in normal and precursor regions were melanocytic (defined as SOX10+ MART1+, Fig. 2A–C, Supplementary Fig. S2A,B, Supplementary Table S4). This evidence concerns the gene MLANA and neoplasm.