Similarly, the essentiality score, which is the normalized growth reduction resulting from gene inactivation, across all cancer cell lines showed a negative essentiality score for WWTR1 in BRAFV600E mutant cancer cells compared to the non BRAFV600E cells (one-sided Wilcoxon rank-sum test, p = 0.0042; n = 68 BRAF V600E cell lines, n = 67 other BRAF mutant cell lines, n = 941 BRAF wild type cell lines; Lee et al., 2021). This evidence concerns the gene WWTR1 and cancer.