Point mutations to tau protein’s primary sequence is causative for familial forms of Frontotemporal Dementia (FTD) (Delisle et al., 1999; Iijima et al., 1999) and increases in tau protein post-translational modifications are linked to a swath of tauopathies, including FTD and AD (Wesseling et al., 2020). This evidence concerns the gene MAPT and tauopathy.