For the different diagnosis of the NC, MCI, and AD groups, retinal Aβ42 alone demonstrated superior AUC values compared with the other retinal markers (Cp, NLRP3, and CCasp3) alone, whereas retinal atrophy in combination with retinal Aβ42 showed the highest mean AUC for diagnosing AD status (Suppl. The gene discussed is NLRP3; the disease is Alzheimer disease.