The current study demonstrates strong associations between retinal Cp burden and retinal amyloidogenic hallmarks of AD, specifically Aβ42 and Aβ40 alloforms, with moderate to lack of associations to retinal tauopathy isoforms such as PHF-tau, CitR209-tau, tau oligomers, pS396-tau, AT8+ p-tau, and MC1+ tangles. Here, ATP7A is linked to Alzheimer disease.