Out of the 787 proteins that constitute the Chlamydia interactome, ~13% proteins were dysregulated in the AD retina and brain, with ten proteins were similarly altered in both tissues, including reticulon 4 (RTN4), TECR, STT3B, TMED4 and AP2M1, which were downregulated, and HSPB1, TPM3, BAG3, LRRFIP1 and ATP6V1G1, which were upregulated. Here, RTN4 is linked to Alzheimer disease.