After restricting our analysis to variants with a gnomAD allele frequency (AF) of <0.001 and a combined annotation-dependent depletion (CADD) phred score of >30, a modest number of potentially deleterious variants were found (Fig. S3A N370S/N370S), but none had an established association with PD, other than the N370S GBA1 variant. Here, GBA1 is linked to Parkinson disease.