This pathway has the potential to help explain PD risk associated with other mild GBA1 variants, such as E326K (p.E365K), which is prevalent in PD cases13 yet does not cause GD55, and the recently identified African ancestry-specific GBA1 noncoding variant that interferes with the splicing of functional GBA1 transcripts, resulting in slightly reduced GCase levels and activity14. The gene discussed is GBA1; the disease is Parkinson disease.