The most upregulated miRNA from HRH1 stimulation, miR-502–3p, was associated with multiple enriched pathways related to insulin resistance, including EGFR tyrosine kinase inhibitor resistance, AGE-RAGE signaling pathway in diabetic complications, and pancreatic cancer (Supplemental Fig. S5A). The gene discussed is HRH1; the disease is familial pancreatic carcinoma.