Additionally, the top hub genes identified in the PPI network of FZD4 miRNA targets, including MYC, EGFR, MDM2, and CDK1 (Supplemental Fig. S4), were also involved in many aspects of cancer progression (Gabay et al., 2014; Oliner et al., 2016; Sigismund et al., 2018; Wang et al., 2023). This evidence concerns the gene MDM2 and cancer.