TPPP and multiple sclerosis: Among these, in three of the four PNG haplotypes, we observed a cluster of insertions along the TPPP/CEP72 locus (Figs. 2D and S16); of which, a 94 bp sequence is inserted in the fourth exon of TPPP, which has known associations with diseases such as cystic fibrosis, chronic kidney disease, and multiple sclerosis(34, 35).