Among these, in three of the four PNG haplotypes, we observed a cluster of insertions along the TPPP/CEP72 locus (Figs. 2D and S16); of which, a 94 bp sequence is inserted in the fourth exon of TPPP, which has known associations with diseases such as cystic fibrosis, chronic kidney disease, and multiple sclerosis(34, 35). This evidence concerns the gene TPPP and chronic kidney disease.