STAT3 and cancer: ID8 p53 (−/−) versus WT cells (Figs. S2B and S2C): Applying Ingenuity Pathway Analysis (IPA) and Chord revealed activation of several oncogenic pathways in the p53−/− cells, including c-MET signaling, the STAT3 pathway and catabolism of branched-chain amino acids, a source of essential nutrients required for cancer growth [29].