In the study by Park et al., adipocyte-specific DNMT1 deficient mice gained significant more weight even on a normal chow diet, and were further prone to diet-induced obesity when fed a high fat diet (56); whereas in our hands, our AD1KO mice had lower adiposity when fed a high fat diet, albeit with no changes in body weight. This evidence concerns the gene DNMT1 and obesity due to melanocortin 4 receptor deficiency.