Following Dex treatment, the GRα and HDAC2 levels in GPX4-cko COPD model mice were significantly elevated, whereas serum CXCL1 levels decreased markedly; in contrast, in GPX4 f/f COPD mice, the levels of these proteins were not significantly normalized after Dex treatment (Fig. 8A to C). Here, HDAC2 is linked to chronic obstructive pulmonary disease.