Both GPX4 f/f and GPX4-cko mice were divided into 3 experimental groups: the control group, COPD group (exposed to CS for 2 months), and Dex group (exposed to CS for 2 months and administered Dex at a dose of 1 mg/kg every 2 d by intraperitoneal injection). This evidence concerns the gene GPX4 and chronic obstructive pulmonary disease.