Neutrophil-specific knockout of GPX4 increased glucocorticoid sensitivity in COPD model mice, as demonstrated by a significant reduction in lung damage in GPX4-cko COPD model mice (Fig. 8D) and a marked decrease in the levels of inflammatory factors in the BALF after Dex treatment (Fig. 8E to G). Here, GPX4 is linked to chronic obstructive pulmonary disease.