In addition, its immunomodulatory effects are significant; for example, Moon et al. (2020) found that BAT from mice with collagen‐induced arthritis exhibited elevated phosphatidylinositol 3‐kinase/Akt signaling pathway (PI3K‐AKT) and interleukin 17 (IL‐17) levels compared to normal BAT, indicating potential benefits for autoimmune diseases. This evidence concerns the gene AKT1 and autoimmune disease.