This results in antibody-dependent cellular cytotoxicity (ADCC) which induces NK effector functions and subsequently results in tumor cell lysis.28 To improve the capability of mAbs to recruit NK cells and thus target and eradicate tumor cells, there are several strategies aimed at boosting the Fc-mediated functions.29 One promising approach is the introduction of amino acid mutations into the Fc part such as the S293D/I332E (SDIE) modification to selectively increase the affinity for FcγRIIIa.30 This evidence concerns the gene FCGR3A and neoplasm.