Asymptomatic cases may not require immediate treatment but are monitored regularly, while symptomatic cases like Waldenström's macroglobulinemia, cold agglutinin disease, IgM-associated peripheral neuropathy, Schnitzler syndrome, or IgM-associated amyloid light-chain amyloidosis may require intervention [8]. Here, CD40LG is linked to Waldenstrom macroglobulinemia.